CD278 (ICOS) Antigen

The CD278 antigen, also known as ICOS molecule (inducible T-cell costimulator, Inducible Costimulator), is a disulfide-linked homodimeric T-cell surface glycoprotein of 55-60 kDa, which belongs to the CD28 and CTLA-4 cell-surface receptor family. The CD278 molecule plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. While CD278 antigen is not constitutively expressed on naïve peripheral blood T cells, it is highly expressed on unstimulated thymocytes of germinal centers, showing a role in T cell differentiation. Upon activation by antigen presenting cells, T cells (CD4 positive cells and CD8 positive cells) express inducible co-stimulatory receptors, including CD28, CTLA4 and ICOS. The resulting interaction of CD278 (ICOS) with its ligand ICOS-L (B7-like molecule present on B cells) participates to interleukin production, especially IL-10 and IL4. The central role of CD278 in the generation and maintenance of humoral immunity has also been shown to be important. Upon the co-stimulation of T cells through ICOS and CD28, ICOS binds its ligand ICOS-L leading to IgG and IgM secretion as well as IgE production. It is not expressed on resting peripheral T cells, B cells, NK cells, monocytes/macrophages, platelets and granulocytes.

 Clone: ISA-3  Isotype: IgG1 Mouse


Explore Beckman Coulter CD278 (ICOS) Conjugated Antibodies

Part Number Product Name Status Clone Size List Price Buy
0.5 mL


100 Tests


Product Line Specifications

Format Liquid
Specificity CD278
Form APC
Clone ISA-3
Isotype IgG1 Mouse
Target Species Human
Flow Product Line IOTest
Item Specifications Referenced B36127

The specifications above are not representative of all reagents but only to the item/part number referenced in this Product Line Specifications table. Please view a product's detail page to view all product specifications for that particular reagent. 

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