Use of Cells in Therapeutics Product Development
In cell therapy, cells are introduced into the human body to either replace endogenous dead/non-functioning cells or to modulate dysfunctional cellular mechanisms. Since its establishment, cell therapy has been closely linked to regenerative medicine, under the premise that stem cell transfer could potentially restore tissue/organ damage previously considered irreparable. More recently, the therapeutic potential on non-progenitor cell therapy has been more extensively investigated, particularly the anti-cancer potential of immune cell transfer.
Living cells have become a crucial component in the development of therapeutic products, not only in the bio-pharmaceutical industry development but also in traditional drug discovery programs:
Cell-based assays are used in Small Molecule drug discovery to gather information on biological activity, toxicology, molecular mechanisms and off-target effects.
Produced in living cells typically in fed-batch bioreactors. Cell-based assays are critical for immune system monitoring, including effector cell activation, immune checkpoint modulation, and cytokine signaling.
Multiparametric Approach to Quality by Design
A poorly controlled assay can cause an manufacturing process to appear out of control or result in invalid or re-test scenarios. QbD decreases the product risk and increases process knowledge using a scientific framework.
Automated Cellular Analysis by Flow Cytometry
Automating your single cell flow cytometry assays provides many benefits to the workflow and to your workday. Because every event matters, even happy hour and baseball games.
Explore Immunotherapy Content
The immune system is responsible for safeguarding the human body from both external and internal threats. Learn how scientists are using immunotherapies to look at cancers and other diseases.