CD63 Antigen

The CD63 antigen, also known as lysosomal membrane associated glycoprotein 3 (LAMP3), is a member of the tetraspanin (TM4SF) family. Nearly 20 genes encode tetraspanins whose main structural characteristics is their four transmembrane domains. CD63, as other tetraspanins (CD9, CD81, CD82), has recently been reported as forming complexes with VLA-3 and phosphatidylinositol 4-kinase, with VLA-6, CD11/CD18 and tyrosine kinase. CD63 was first described in granules of resting platelets and on the surface membrane on activated platelets. CD63 was later identified as granulophysin, a platelet dense granule glycoprotein. The molecular weight of the platelet form of CD63 ranges from 40 to 55 kDa. CD63 has been found to be identical to the ME491 antigen expressed by melanoma cells. It is also found on monocytes / macrophages and is weakly expressed by resting granulocytes, T lymphocytes and B lymphocytes. CD63 antigen, present in azurophilic granules of non-stimulated neutrophils, is strongly expressed on the surface of neutrophils after activation. Studies have shown that CD63 may be a marker for granule release. This phenomenom is also reported for basophils.


 Clone: CLB-Gran/12  Isotype: IgG1 Mouse

The CD63 antibodies inhibit adhesion of neutrophils to activated endothelium. CLBGran/12 was used as a CD63 reference monoclonal antibody during HLDA 6.
 

 

Explore Beckman Coulter CD63 Conjugated Antibodies

Part Number Product Name Status Clone Size List Price Buy
CE
CLBGran/12
100 Tests

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ASR
CLBGran/12
2 mL

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ASR
CLBGran/12
2 mL

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Product Line Specifications

Format Liquid
Specificity CD63
Form PE
Clone CLBGran/12
Isotype IgG1 Mouse
Target Species Human
Flow Product Line IOTest
Item Specifications Referenced IM1914U

The specifications above are not representative of all reagents but only to the item/part number referenced in this Product Line Specifications table. Please view a product's detail page to view all product specifications for that particular reagent. 


Technical Documents