CD11c Antigen

CD11c (integrin αX subunit, also known as leucocyte surface antigen p150, Axb2 and CR4) is a member of the integrin family. Like other leucocyte integrins (CD11a, CD11b, CD11d), CD11c is non-covalently associated with the β2 integrin subunit (CD18). CD11c is a transmembrane glycoprotein of 145-150 kDa, mainly expressed by monocytes, macrophages and NK cells, and to a lesser extent by granulocytes, dendritic cells and some subsets of T and B cells. CD11c / CD18 has an important role in cytotoxic T cell killing, in the adhesion of monocytes and neutrophils to the endothelium and induces cellular activation. The CD11c is ∼87% homologous in sequence to CD11b, and recognizes similar ligands including complement factor fragment iC3b, fibrinogen, CD54 and bacterial lipopolysaccharide.


 Clone: BU15  Isotype: IgG1 Mouse

The BU15 antibody was used as a CD11c reference mAb (ref.6) during HLDA 6.
 

 

Explore Beckman Coulter CD11c Conjugated Antibodies

Product Line Specifications

Format Liquid
Specificity CD11c
Form PC5.5
Clone BU15
Isotype IgG1 Mouse
Cross Reactivity Canine
Target Species Human
Flow Product Line IOTest
Item Specifications Referenced B19719

The specifications above are not representative of all reagents but only to the item/part number referenced in this Product Line Specifications table. Please view a product's detail page to view all product specifications for that particular reagent. 


Technical Documents